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5-MeO-DMT is a research chemical psychedelic of the tryptamine class, four to six times more powerful than its better-known cousin, DMT (N,N-dimethyltryptamine). It can be found in a wide variety of trees and shrubs, often alongside DMT and bufotenine (5-HO-DMT), as well as one species of toad. 5-MeO-DMT can also be synthetically produced.

In Central and South America, 5-MeO-DMT is most often sourced from Anadenanthera peregrina (yopo or cohoba) and Virola theiodora—both of which are traditionally harvested to make psychoactive snuff.

It’s also found in the milky white venom of the Sonoran Desert Toad (Bufo alvarius/Incilius alvarius; aka the Colorado River Toad ), which is native to the southwestern United States and northwestern Mexico. Venom harvesting has put pressure on the population of this ecologically sensitive species. It’s currently listed as imperiled or locally instinct in several states in the US. Seeking out alternatives sources of 5-MeO DMT, such as synthetic or plant-derived versions, is strongly recommended.

In keeping with its ceremonial use among indigenous Amazonians, 5-MeO-DMT shows great promise in the treatment of certain medical conditions. In fact, a single inhalation of the substance has been shown to greatly improve general well-being and mindfulness as well as reduce the symptoms of psychological disorders.

While research into 5-MeO-DMT is limited, a few studies have supported the anecdotal evidence. In a recent preliminary study, 42 participants who took 5-MeO-DMT reported high levels of life satisfaction and mindfulness as well as lower levels of depression and anxiety. The effects persisted for four weeks, when a follow-up assessment was completed.

These results support the findings of a survey of 362 people who had taken 5-MeO-DMT. After using the psychedelic, 80% of respondents reported improvements in anxiety and depression.

5-MeO-DMT has seen a meteoric rise in popularity over the past few years as anecdotal reports of its potential as a healing agent have come to light. This has incentivized some bad practices among guides and other practictioners, including everything from overharvesting and the ecological strain on Sonoran Desert toad mentioned above, as well as sexual abuse and even unintended deaths in several documented cases.



5-MeO-DMT is one of the most potent psychedelics you can consume, and the experience can be intense and powerful—in both positive and negative ways. Though everyone will undergo a unique and individual experience, there are some general things you can expect.

What to Expect

Vaporizing or smoking 5-MeO-DMT powder is the most common route of administration. The effects are usually felt within the first 30 seconds after consumption, peaking from 1-15 minutes and lasting for up to half an hour. When taking synthetic 5-MeO-DMT, a threshold dose is around 1-2 mg, while a moderate-to-strong dose is 5-10 mg. When naturally derived, the threshold dose is 5-10 mg and a moderate-to-strong dose is 20-40 mg.

When swallowed, doses are generally higher, but also show generally unreliable results. Other less common routes of administration include sublingual (under the tongue) and injection.

The effects of 5-MeO-DMT come on strong, often with a loss of physical coordination and control. Users experience bright colors, moving environments, or recursive patterns, and perhaps even “environmental orbism” at higher doses. However, visual effects are limited. Unlike DMT, 5-MeO-DMT isn’t known for its visionary properties. The experience is more often described as a “perspective shift” characterized by physical, emotional, and conceptual effects.

One of the most common features of the 5-MeO-DMT experience is the enhancement of tactile awareness, which can reach the point of sensory overload. The body may also feel heavier. Intense emotions are typical, ranging from extreme fear to euphoria. During the onset, anxiety or excitement are often felt. It’s also common to experience an overwhelming sense of oneness with the universe, or a sense of being outside of time and space while simultaneously experiencing the totality of both. Ego death is also typical of the 5-MeO-DMT experience. Other effects include auditory hallucinations, time distortion, nausea, and memory loss


Like the other tryptamines, 5-MeO-DMT has the same basic structure as , but has a methoxy group in the R5 position. It works primarily as a serotonin (5-HT) receptor agonist, with a particular binding affinity to the 5-HT1A receptor subtype. It also binds to 5-HT2A and trace amine receptors, possibly mediating hallucinogenic effects via the latter. Reuptake inhibition of neurotransmitters such as noradrenaline and dopamine are also thought to be involved in 5-MeO-DMT’s function.


There is some evidence that indolealkylamines, including 5-MeO-DMT, cause serotonin syndrome when overdosed or combined. Of particular concern are possible interactions with monoamine oxidase inhibitors (MAOIs) such as harmaline or harmine. These are sometimes combined with the drug to enhance its effect, but can dangerously increase exposure to both 5-MeO-DMT and its active metabolite bufotenine.

Some other safety concerns have been flagged by animal studies. In rats, 5-MeO-DMT was found to induce hypothermia at low doses (0.5-1 mg/kg) and hyperthermia at high doses (3-10 mg/kg). In sheep, grazing on the 5-MeO-DMT-containing Phalaris tuberose/aquatica (or bulbous canary-grass) caused fatal tachycardia and respiratory failure.Although more likely due to other toxins in the plant, this severe reaction underscores the need for caution when approaching 5-MeO-DMT’s many and varied natural sources.


5-MeO-DMT doses are different depending on whether the substance is synthetic and naturally derived.


Small: 3-6 mg
Medium: 6-10 mg
Large: 11-15+ mg


Small: 10-20 mg
Medium: 20-40 mg
Large: 40-60+ mg



Potential Benefits

5-MeO-DMT has been used as a healing agent by South American shamans for thousands of years, partially due to its ability to occasion mystical-type experiences. While research into the drug is still limited, recent studies are backing up these ancient claims.

In a survey of 362 adults, 80% of respondents reported improvements in anxiety and depression after using 5-MeO-DMT, as well as an increase in well-being and life satisfaction. More than that, improvements were directly related to the intensity of the mystical effects felt during the experience. Respondents that had intense mystical experiences also reported higher rates of the experience’s personal meaning and spiritual significance.

The benefits of 5-MeO-DMT have also proven to be enduring—in a recent preliminary study,[76] 42 participants who took 5-MeO-DMT reported an increase in levels of life satisfaction and mindfulness as well as lower levels of depression and anxiety. The effects persisted for four weeks after the initial experience when a follow-up assessment was completed.

One of the unique aspects of 5-MeO-DMT is the short duration of the experience compared to more common psychedelics, such as LSD and psilocybin. While research has shown that psychedelic-assisted psychotherapy can help people with a variety of psychological disorders, these sessions often require a 7 to 8-hour session. Because 5-MeO-DMT is short-acting and lasts just 30-90 minutes, it shows promise as an accompaniment to therapy sessions, which are typically 60 to 90 minutes.


A recent study from The Journal of Psychopharmacology found that 5-MeO-DMT is safe to use and has a low risk of health consequences.

However, there are some things to be aware of before diving into an experience. 5-MeO-DMT should not be taken with MAOIs, including some antidepressants. Combining them may cause severe hypertensive symptoms (elevated blood pressure, heart rate, and temperature), seizures, long-term kidney damage, serotonin syndrome, and even death.

Because of the somewhat unpredictable nature of 5-MeO-DMT, a sitter is definitely recommended. Short-term unconsciousness, respiratory depression, and delusional interactions with the environment are some of the things to watch out for. At the very least, it should be taken in a comfortable seated or lying position to avoid falling over.

Those new to 5-MeO-DMT should start out with a low dose, weighed on a scale accurate to 0.002 g (2 mg). Since people tend to react differently to the same doses (and it’s not entirely clear why) caution is advised, even if you have prior experience of tryptamines.

As with any psychedelic, follow the 6Ss of psychedelic use to minimize the risks of a bad experience.



While clinic research into 5-MeO-DMT’s therapeutic use is limited, the psychedelic has been shown to alleviate depression, anxiety, PTSD, and addiction. It’s also sometimes used alongside ibogaine treatment to help patients integrate their experience.

In the past few years, however, interest in 5-MeO-DMT has grown, along with research. In one study, researchers gave 5-MeO-DMT to mice and found a major downregulation in mGluR5, a receptor involved in the reward mechanism of drug abuse. Not only are mice without the mGluR5 gene less likely to self-administer cocaine and ethanol, they also show less severe symptoms of nicotine withdrawal. Furthermore, cells treated with 5-MeO-DMT showed an upregulation of integrins. Antidepressant medications create a similar response, suggesting that 5-MeO-DMT could have antidepressant properties.

As previously mentioned, in two recent surveys totaling more than 400 people, the vast majority reported improvements in anxiety and depression after using 5-MeO-DMT, as well as an increase in well-being and life satisfaction. For some, the experience also helped them recover for PTSD or addiction.

The John Hopkins Center for Psychedelic Research is beginning to study the effects of 5-MeO-DMT, with researcher Alan Davis believing the drug could be effective at treating mental illness due to neurological changes in users’ brains caused by the substance as well as insights gained through the psychedelic experience.

Dr. Joseph Barsuglia, Clinical Research Director at Mexico’s Crossroads Ibogaine Treatment Center, is also researching 5-MeO-DMT as a potential treatment for addiction. He believes that using 5-MeO-DMT in partnership with the psychedelic ibogaine could prove to be a powerful combination for eradicating issues of substance abuse. “People are talking about melting into God, being united with the universe, clearing longstanding trauma and pain that was stored in their bodies,” he said. “We’re finding that the combination of [5-MeO-DMT and ibogaine] is like… 1+1=5. It’s just exponential.”

Additionally, 5-MeO-DMT appears to have a placebo analgesic effect comparable to hypnosis. Like the other classical psychedelics, it may be useful in the treatment of acute and chronic inflammatory conditions, including some cancers.

More indirectly, 5-MeO-DMT is also helping researchers better understand the neurobiological basis of schizophrenic hallucinations—ultimately paving the way for more effective antipsychotic drugs.


While 5-MeO-DMT shows promise as a therapeutic tool, the drug has been used for centuries as a tool for personal and spiritual growth. In fact, a recent survey from Davis and Barsuglia found that most users of 5-MeO-DMT used the drug for spiritual exploration and reported intense mystical-type experiences, including ego death.

This experience is often described in positive terms—even if it was terrifying at the time. Many see it as a process of death and rebirth followed by lasting self-improvements, including mental clarity, increased motivation, enhanced awareness, joy in living, and a sense of inner peace. Some have also had enlightenment experiences, characterized by a sense of inseparability from the universe or of being “all that exists.”Often, these experiences come in waves or reactivations over the following days or weeks.

Being forced to let go of the ego is precisely what draws many people to 5-MeO-DMT. The dissolution experience can impart an understanding and acceptance of mortality that helps people overcome the fear of death. It can also heal past trauma, negative behaviors, and habitual negative thought patterns.

One group of 5-MeO-DMT ‘practitioners’ have also reported that there are a number of specific integration and grounding techniques to increase the potential for growth. These include acupuncture, massage, physical exercise, certain foods, and even just talking to others. Interestingly, they advise against meditation because it could end up prolonging the grounding/integration period by triggering additional reactivations.



5-MeO-DMT legality in USA

5-MeO-DMT is a Schedule I controlled substance in the US, making it illegal to manufacture, distribute, possess, or buy. 5-MeO-DMT-containing plants, however, are generally not controlled, particularly in Oakland, CA, all “entheogenic plants” were decriminalized in 2019. This allows adults aged 21 years and older to use them either medicinally (in accordance with the resolution’s official intent) or for any other reason without fear of criminal punishment. It also specifically decriminalizes (or rather deprioritizes for law enforcement) their cultivation and distribution.

5-MeO-DMT legality in Canada

Some people choose to buy 5-MeO-DMT in Canada, where the substance is not controlled. However, it should go without saying that a 5-MeO-DMT supplier in Canada cannot legally ship the substance to a country where it remains illegal.

5-MeO-DMT legality in Mexico

The legal status of 5-MeO-DMT in Mexico is similar to Canada. However, it has a less clandestine feel south of the border; 5-MeO-DMT retreats are actually quite common in Mexico.

5-MeO-DMT legality elsewhere

Laws prohibit the use of 5-MeO-DMT in the UK, Australia, New Zealand, and many European countries. In Denmark, it’s permitted for use in research.


5-MeO DMT and the Sustainability of the Sonoran Desert Toad

Though there are several natural and synthetic sources of 5-MeO-DMT, the use of “toad medicine” has become venerated, increasing its demand in Mexico, the United States, and in some countries in Europe and South America. This has put a strain on the Sonoran Desert Toad (Bufo alvarius) population, whose habitat is relatively small, spanning southeastern California, southern Arizona, southern New Mexico, and northwestern Mexico.

In the United States, there are ongoing efforts to add the Sonoran Desert toad to the endangered species list. And while it’s not currently listed as a protected species at the federal level, it is considered imperiled in New Mexico and possibly locally extinct in southern California.

Though the International Union for Conservation of Nature (IUCN) does not classify the toad as an endangered species, the classification dates back to 2004, which doesn’t reflect the recent surge in interest in the toad’s therapeutic and psychedelic potential. In addition to endangering the population, this is also causing the toad to become a victim of black market trafficking as well as inhumane breeding and “milking” practices in captivity.

The destruction of the toad population can be avoided by using synthetic 5-MeO-DMT instead of vapor from the toad. Many people believe toad medicine is superior because of its “purity”, but there is no evidence that 5-MeO-DMT derived from toads produces a better/different experience or outcome than synthetic 5-MeO-DMT.

Cultural Ethics

Cultural considerations also need to be taken into account. A group of eight indigenous cultures originally from the Sonoran Desert have started promoting the use of the substance as an effort to revive their cultural identity. There is some debate as whether or not toad medicine was used in these cultural practices prior to Ken Nelson’s discovery of the toad’s psychoactive effects.

In either case, the use 5-MeO-DMT into the indigenous cultures of the US has also brought it into the reclamation of ancestral medicine in Mexico.

While these groups traditionally use peyote, mushrooms, ayahuasca, and iboga in their ceremonies, the Bufo alvarius toad is now joining (or rejoining) the list.

This brings up the question of cultural appropriation. Toad medicine is being used in locations and contexts that are very different from the indigenous cultures in which it originated.

Small scale, local use of the toad-derived 5-MeO DMT in indigenous practices is much more likely to be sustainable and arguably more ethical, especially when considering many of these populations don’t have access to alternatives. But beyond local use, where plant-based and/or synthetic alternatives are more easily accessible, it’s difficult to argue for harvesting the toad-derived compound at scale.

Ethics Violations Among Guides

Psychonauts, neohealers, therapists, and urban shamans alike are becoming 5-MeO-DMT facilitators, and retreats offering the drug in ceremonial settings for profit are popping up in Mexico and South America.

While this has caused friction with practitioners from indigenous cultures, it’s also created a market for charlatans taking advantage of people under the influence of 5-MeO-DMT and not in control of their bodies. Two such practitioners—Gerardo Sandoval and Octavio Rettig—have been accused of sexual abuse, psychological manipulation, intentional overdosing, physical violence, hospitalizations, and, in Rettig’s case, at least four deaths.



Traditional use of 5-MeO-DMT in the Americas goes back hundreds—maybe even thousands—of years. Ancient snuffing paraphernalia and traces of the compound found in northern Chile date the practice to at least the 8th century. The use of 5-MeO-DMT-containing snuff was first recorded in 1496 by Friar Ramón Pané. Reporting to Christopher Columbus on the Taíno people of Hispaniola, Pané observed inhalation of cohoba snuff through reeds. It was often to help sick people purge, as well as a medium to obtain medical diagnoses from spirits.

In 1737, Joseph Gumilla observed a similar practice, with yupa (or yopo), among the Otomac of southern Venezuela. Some time later, Alexander von Humboldt described how the snuff was made. First, the seeds of the Acacia niopo (Adenanthera peregrina) were left to blacken, then mashed into a paste with cassava flour and lime from snail shells. This mixture was dried over a fire and pulverized for use, then inhaled through a Y-shaped bone tube, such as a plover leg, with the forked ends straddling the septum. Another account from Richard Spruce in the mid-1800s described the use of tubes between two people—one to blow the snuff into the nostrils of the other. Spruce also collected specimens of the Adenanthera peregrina for identification.

In 1936, 5-MeO-DMT was synthesized by the chemists Toshio Hoshino and Kenya Shimodaira. But it wasn’t until 1959 that it was finally identified as the major psychoactive component of yopo/cohoba. It was also found in the venom of the Colorado River Toad (Bufo alvarius/Incilius alvarius or Sonoran Desert Toad), sometimes at levels of up to 15% by volume.

From the early 1970s, 5-MeO-DMT could be legally ordered in the US and other countries via mail order from the Church of the Tree of Life and the Church of the Toad of Light. Since scales accurate to the milligram weren’t widely available, it was typically added to parsley or cannabis to help with dosing.

Recreational use steadily increased over the ensuing decades while remaining underground. In the 1990s, ethnobotanist Jonathan Ott and others popularized and developed 5-MeO-DMT for sale on the internet. In 2001, the research chemical vendor Mark Niemoller was arrested under the Controlled Substances Analogue Act of 1986. He was released on house arrest after agreeing to stop selling 5-MeO-DMT and a number of other substances. In July 2004, “Operation Web Tryp” saw the DEA shut down five more 5-MeO-DMT and research chemical vendors, prompting numerous others to stop trading voluntarily. In January 2011, 5-MeO-DMT was declared a Schedule I drug in the United States.

Current use

5-MeO-DMT is often conflated with other tryptamines or “novel psychoactive substances” in major drug surveys, so it’s difficult to gauge how prevalent its use is. However, it’s possible to get a general feel for its popularity over time by looking at Google search statistics. Between 2004 (the year of “Operation Web Tryp”) and 2007, searches for 5-MeO-DMT fell dramatically and have remained at a steady low ever since.


“5-MeO-DMT is a form of DMT”

This myth is based on a common, and potentially very dangerous, misunderstanding of pharmacology. It’s no more a form of DMT than psilocybin is. Although the two substances are chemically related, the effects of 5-MeO-DMT and DMT are substantially different, as are their safety profiles. 5-MeO-DMT, for example, has a much lower toxicity threshold than DMT, so conflating the two could be dangerous.

“Licking toads is an easy way to get high.”

Alexander Shulgin attributed this myth (or rather, very bad idea) to sensationalism in the media. Licking the Colorado River Toad has never been a common method for obtaining 5-MeO-DMT, for the simple reason that it’s deadly. Other chemicals in raw toad secretions are known to be cardiotoxic, which means they’ll disrupt the functioning of the heart. Numerous humans have died after licking toads and one child who was hospitalized with seizures from the venom took a week to recover. Given that just this one, geographically isolated species is known to be psychoactive, there’s also the danger of licking the wrong toad entirely, which can cause death or permanent paralysis.



Can it be detected in a drug test?

5-MeO-DMT isn’t detected in any standard or extended drug tests, nor are there specialized tests to look for it. Also, since it’s unlike other drugs tested for, it shouldn’t trigger a false positive.

Where can I buy 5-MeO-DMT online?

You can usually find 5-MeO-DMT for sale from vendors in Canada, Mexico, and other countries where it isn’t controlled. If you don’t live in one of these countries, however, it’s still illegal to buy 5-MeO-DMT online from a vendor in Canada (for example) and import it.

Can I test my 5-MeO-DMT to see if it’s safe to take?

Testing your 5-MeO-DMT is always good practice even when you trust your supplier.offering peace of mind and potentially saving your life.

The Hofmann and Mecke reagents, for example, can help identify real 5-MeO-DMT. Simply place a tiny amount of 5-MeO-DMT into a sterile test tube or onto a sterile white ceramic surface and add a few drops of the reagent. Then check the color change (or lack thereof) against the supplied spectrum booklet.

Can 5-MeO-DMT cause psychological trauma?

Most people find the 5-MeO-DMT experience overwhelming. Consensus reality, the physical environment, body, and self tend to fall away and behavior can become irrational. While long-term psychosis seems improbable, it may take some time to fully recover from the 5-MeO-DMT experience.

After higher doses, some users have reported persistent psychological difficulties, including paranoia and the subtle (but controllable) resurfacing of effects, that can last for several weeks.

“White-outs” and memory suppression are also common during the 5-MeO-DMT trip itself, negatively affecting users’ ability to form memories of the altered state.

Are there risks?

Taken in the presence of a sitter with no other drugs or contraindicated medications (like MAOI antidepressants), 5-MeO-DMT appears to be relatively safe. That said, persistent anxiety has been reported after just one use, along with sleep disruption and panic attacks. To help minimize the risks, it’s a good idea to start with low, precisely measured doses, and have an experienced sitter present.

Alternatively, you may wish to be in the presence of a more actively engaged facilitator, or ‘practitioner’—a 5-MeO-DMT specialist trained to guide and help integrate your experience. Click here for in-depth tips on how to choose the right person or group for the job and what you should expect them to do.

What should I do in the event of a 5-MeO-DMT overdose?

5-MeO-DMT overdose reports indicate a risk of breathing difficulties and loss of consciousness. If this happens, roll the person onto their side and call the emergency services, keeping them calm until paramedics arrive. A responsible, trained sitter may also need to provide mouth-to-mouth resuscitation after checking the airway is clear.

Is it legal to cultivate natural 5-MeO-DMT sources (5-MeO-DMT plants, 5-MeO-DMT toad species, etc.)?

Cultivating plant sources of Schedule I drugs is a bit of a legal grey area (except in specified cases like cannabis and peyote, and where entheogenic/psychedelic plants are specifically decriminalized). While the law prohibits “any material containing any quantity” of illegal substances, the likelihood of prosecution is slim. On the other hand, 5-MeO-DMT extraction from any source is definitely illegal and will lead to prosecution if caught.

Regarding toads, the rules are clearer. In New Mexico, only state residents may collect them without a license. Both residents and non-residents of Arizona need a fishing license to collect a maximum of 10 Colorado River Toads. In California, meanwhile, it’s a misdemeanor to collect toads and possession is against the law. Regardless of the legality, though, the Colorado River Toad is a threatened species. Keeping toads in captivity—not to mention regular “milking”—is found to damage their health.

What’s the safest way to take it?

There is no entirely safe way, but vaporizing or smoking 5-MeO-DMT powder is by far the most tried and tested. The onset of effects is shorter than with insufflated or sublingual use. However, some people experience chest pains from the smoke. Others experience no effects whatsoever and prefer intravenous or intramuscular injections. These induce rapid, intense effects even at low doses. Swallowing the drug isn’t recommended due to safety concerns and it’s often ineffective anyway.

Can I microdose with 5-MeO-DMT?

As people’s reactions vary immensely, it’s hard to give a reliable microdose range. Some have felt profound effects on less than a threshold dose, while others experience only mild effects from a moderate dose.

Can I develop a tolerance?

Yes, tolerance develops almost immediately and takes two hours to return to baseline. There is no cross-tolerance with other psychedelics.

Can I mix it with other drugs?

It shouldn’t be mixed with MAOIs or RIMAs, including some antidepressants, due to the risk of serotonin syndrome and death. Releasing agents and reuptake inhibitors, for serotonin and dopamine especially, can be dangerous in combination. For this reason, mixing 5-MeO-DMT with other psychoactive drugs is discouraged. Combining with alcohol is strongly discouraged due to the risk of vomiting and subsequent choking.

Is 5-MeO-DMT similar to 5-MeO-MiPT, 5-MeO-DALT, 5-MeO-DiPT, etc.?

Not necessarily. Substances in the 5-MeO group may share some basic similarities, but effects and safety can vary. Dosage in particular tends to vary significantly, as does legal status—so it’s unwise to assume they’re interchangeable.

Here’s a brief overview:


5-MeO-MiPT, or Moxy, can be taken orally (e.g. as 5-MeO-MiPT HCl) or smoked (as freebase). Threshold effects may be felt from as little as 1-2 mg taken orally (or 10-15 mg 5-MeO-MiPT if smoked). 15+ mg is considered strong or heavy and the experience can last 5-8 hours. Some people use 5-MeO-MiPT for sex. Although it’s possible to buy 5-MeO-MiPT online in the USA, its legal status is unclear.


5-MeO-DiPT, also known as Foxy or Foxy methoxy, is entactogenic and sexual, similar to 5-MeO-MiPT. It’s usually taken orally as 5-MeO-DiPT HCl (3-15+ mg) and has a duration of up to 8 hours. Although a Schedule I substance in the USA, in Canada, 5-MeO-DiPT is legal.


5-MeO-DALT is taken orally as 5-MeO-DALT HCl at a dosage of 4-30+ mg. Like the 5-MeOs described above, it’s mildly psychedelic and often used for sex. Apparently, it also helps alleviate cluster headaches. You might find 5-MeO-DALT for sale in the USA, given that it’s unscheduled—outside of Florida, at least. But it may be considered an analogue of 5-MeO-DiPT.


5-MeO-aMT, or Alpha, has a reported threshold dose of just 0.5 mg, and 6-15 mg may be heavy. Effects are said to last 8-12 hours. On Erowid, 5-MeO-aMT is linked to a number of hospitalizations and possible deaths following overdose (ranging from 5-50 mg). It’s reportedly unscheduled in the USA—with the exception of Florida.

Other 5-MeOs

  • 5-MeO-pyr-T: potentially dangerous at just 0.5-3 mg*
  • 5-MeO-MALT: reportedly euphoric at 15-50 mg oral*
  • 5-MeO-DET: uncomfortable drunk feeling at 1-3 mg oral*
  • 5-MeO-TMT: sexually stimulating at 65-90 mg; nauseating at 120+ mg
  • 5-MeO-BFE (aka dimemebfe)
  • 5-MeO-DiBF
  • 5-MeO-NiPT
  • 5-MeO-DPT
  • 5-MeO-NMT
  • 5-MeO-MET

* dose/effects based on limited reports and by no means definitive; included only to give a sense of the variation within the 5-MeO group of substances

When The Drop Joins The Ocean: An Evidence-Based And Personal Exploration Of 5-MeO-DMT

The revival of psychedelic science and research has produced a fascinating wealth of information about their therapeutic potential. From treatment resistant depression to PTSD and addiction, psychedelic medicine is proving to be a powerful tool for healing the human race. One of the most surprising discoveries is the incredibly powerful psychedelic known as 5-MeO-DMT.

Produced naturally in some plants, and most notably, in the venom of the Sonoran desert toad, Bufo Alvarius, 5-MeO-DMT was discovered only 30 some years ago. Since that time, it has been reported to produce one of the most powerful and profound psychedelic experiences known to man. This guide will explore the mystical 5-MeO-DMT experience, it’s potential therapeutic applications and spotlight advanced 5-MeO-DMT practitioner Joël Brierre of Kaivalya Kollectiv, who I had the pleasure of partaking in the 5-MeO-DMT experience with.

What is 5-MeO-DMT?

5-MeO-DMT is a powerful psychedelic in the tryptamine class of compounds found in many plant species and at least one toad species. Seeds containing 5-MeO-DMT and bufotenin have been used in South American entheogenic rituals in a snuff preparation known as yopo. However, recent studies have shown the bufotenin is largely responsible for the hallucinogenic effects of yopo due to the extremely limited amount of 5-MeO-DMT.

What Does the Research Say About 5-MeO-DMT?

The state of clinical research around this compound is still very limited. However, early results do show great promise. In fact, a recent study found that:

“A single inhalation of the psychedelic drug 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is associated with sustained improvements in satisfaction with life, mindfulness, and a reduction of psychopathological symptoms, according to preliminary research published in Psychopharmacology.”

It is also important to note that such a powerful mystical experience is paired with a period of significant neuroplasticity and neuronal growth. Another study found that:

“A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus”

Essentially, a single dose of this powerful psychedelic stimulated cell growth, survivability, and changes to the shape and function of brain cells in adult mice. Thus, the importance of an important integration program and conscious activities immediately before and after working with the medicine is particularly important.

Comparing and Contrasting DMT and 5-MeO-DMT

While the name may imply this newly discovered compound is similar to the classic psychedelic DMT, or dimethyltryptamine, the 5-MeO-DMT experience is robustly different and distinctly unique. Both DMT and 5-MeO-DMT have an incredibly rapid onset, are fast acting and have a short duration, sometimes lasting only seven minutes. However, this is where the similarities end.

While the DMT experience is highly visual, full of colorful fractals and sacred geometries, your thoughts still remain coherent. On the other hand, the 5-MeO-DMT experience shatters all senses of self, any concept of “I” that may exist and fully merges your being with the universe itself. The unique separation of self from the mind in the 5-MeO-DMT experience removes the element of fear that is often present in the regular N,N-DMT experience.

However, managing fear before one’s first experience can certainly be a normal part of the process and something I certainly experienced before my first time smoking 5-MeO-DMT. This is where an experienced guide really comes in handy. Unlike regular N,N-DMT, 5-MeO-DMT cannot be safely administered alone and requires a skilled guide who can safely tend to your physical body while one is in the experience.

A Note About Utilizing Natural Toad Venom Versus Synthetic 5-MeO-DMT

It is important to note that currently, no evidence supports the idea of that consuming toad venom is any more or less beneficial than the synthetic molecule. Phenomena such as the “entourage effect” have not been established in secretions from the toad. Hamilton Morris in his riveting series, Hamilton’s Pharmacopeia, connected with the first human to smoke toad venom, Ken Nelson (also known as Albert Moss). Their fascinating dialogue about sustainability with 5-MeO-DMT supported the idea that the pure synthetic molecule is the ideal path forward. He states that the only reason to milk the toads is to analyze venom and find a way to fully recreate it synthetically so we don’t have to bother toads. Indeed, expert 5-MeO-DMT practitioner Joël Brierre of Kavilaya Kollectiv utilizes the pure molecule with remarkable results.

My Personal Experience Smoking 5-MeO-DMT Under the Care of Joël Brierre of Kaivalya Kollectiv

While I feel now that there is no way one can truly prepare for such a powerfully divine experience, I believe that Joël Brierre of Kaivalya Kollectiv and his beautiful partner, Victoria Wueschner, do an incredible job. I had a considerable amount of pre-flight anxiety and fear around engaging with this medicine. DMT comes on fairly strong for me, so I felt that something even more powerful would be truly overwhelming. Indeed, the experience was the most overwhelming moment of my life, but in the best and most necessary ways.

Experiencing A Deep Understanding of the “Oneness” of All Things

Although my mind wasn’t present during my journey, I still had a deep understanding of the “Oneness” of all things. My inner knowing that I was merging with the infinite, like when the drop joins the ocean, made the experience incredibly cathartic and moving for me. There was a moment where I realized that we as humans had “forgotten” our true nature and our deep connection to source energy. This realization made me intensely sad and I cried more deeply than I ever have in my life–perhaps all my lives. Such powerful moments were intertwined with an intense patchwork of love and connectedness that I had never felt before.

Purging Ancestral Trauma & An Important Note About Safety During the Trip

This medicine requires caretakers who can help the user during their trip, which is one of the biggest differentiators from DMT. In my second session (I went in 3 times total), I had to purge and I’m incredibly grateful Joël and Victoria were able to care for me in that vulnerable moment of mine. Indeed, I had gone in the second time with the intention of releasing deep ancestral trauma and it truly felt like that was happening in my purge.

This purge highlighted an important note about safety when working with this medicine. While I was laying on my back for most of the trip, it was necessary for those caring for me to make sure I could be rolled into a recovery position to vomit to prevent aspiration and choking. Unfortunately, there have been deaths before due to this happening when the medicine is taken under the supervision of unskilled providers, or perhaps, taken alone, which is much more dangerous. I’m grateful for the presence of Joël and Victoria during this process who helped me smoothly overcome this moment during my process.

Round Three Culminates Perfectly In the “Cosmic Joke”

Joël and Victoria set up what they call the “lily pad”, a comfortable altra where the medicine is administered, right by their swimming pool. This pool is filled with highly amusing inflatable animals with very animated expressions. In particular, there is a shark Joël calls “Drago” who has a smile I find genuinely amusing.

This is significant because after coming out of my last trip, overcome by powerful emotions of love, gratitude and awe, I looked over the pool only to see Drago the inflatable shark flying across the water as if he was coming right at me. The three of us saw this happen and burst out laughing in the most satisfying laughter I’ve experienced in a while. Described as the “cosmic joke”, this occurrence reminded not to take life, even such a profound experience, too seriously.

The Value of an Experienced Practitioner Cannot be Overstated

Smoking the 5-MeO-DMT was the most deeply mystical and profoundly spiritual experience of my life. Having worked with several plant medicines, including ibogaine, ayahuasca, peyote, kambo, and more, I believe the value of an experienced, compassionate and skilled practitioner cannot be overstated. Joël and the team at Kaivalya certainly have this delicate and powerful process down to an art. I’m grateful for having the opportunity to sit with him for this ceremony and get his insights for this piece.

Joël Brierre Shares Deep Insights on Working With 5-MeO-DMT

One of the main things that keeps me inspired to serve this medicine is how relevant the experience is to what we’re going through as a collective. This is a medicine that unlike any other psychedelic, produces a full cessation of self activity, or a total dissolution of ego, allowing the participant to experience a real, palpable oneness with not just everything in this world, but seemingly with source, or the Godhead itself. This merging into the infinite has been a tenet of nearly every faith and spiritual practice since man first looked to the heavens, this mystical experience has been described throughout many cultures under many different names, whether it be Samadhi to the Yogis, Nirvana to the Buddhists, the Beatific Vision to the Christians and Catholics, or Fitrah in Islam, this experience has had entire religions built around it. The ancient alchemists, sages, and mystics referred to this great mystery as the ineffable, or that which cannot be known or described, thus a religion or spiritual practice can only serve as a lens through which one can take in, or experience this great mystery.

Why I find this so relevant to the current state of the world, is that once someone has been immersed in the waters of the infinite, one is able to feel the perfection of the universe in a completely new way, the chaos and order flow and dance together as two parts of the same whole, upon returning to self, worries and anxieties are seen through a whole new lens. We can understand non-duality and oneness conceptually, however to be initiated into this great remembrance in a real and experiential way is to remember our wholeness, to remember the immense beauty in this play of existence. To remember this truth requires a sacrifice of all that allows you to feel separate, a sacrifice of all that is familiar, with this death of the assumed self comes a falling away of inner turmoil, and thus comes rebirth, and what a beautiful time to be reborn.




This is an extremely potent natural psychedelic present in certain plants and the poisonous secretions of the Sonoran Desert Toad. That been true, its is also know as the Colorado River Toad. It can also be produce synthetically in a lab. This is the short for 5-Methoxy-N,N-Dimethyltryptamine. This drug stands out to be one of the most powerful psychedelic existing.

Where can I buy 5-MeO-DMT online?

At gettrippyshop ,  you get a wide variety of psychedelics and psychoadictive drugs, with our product standing out as head. The chance to get the best shot out of this drug in the form of a powerful “yopo,” or powder blown forcefully into the nose. Being somewhat more obscure than DMT, the potential of 5-MeO-DMT for healing substance addiction is less well known, but some progressive treatment centers have found it extremely useful.


Finding you right Dosage

Taken in the presence of a sitter with no other drugs or contraindicated medications (like MAOI antidepressants), it appears to be relatively safe. Otherwise, persistent anxiety has been report after just one use, along with sleep disruption and panic attacks. To help minimize the risks, it’s a good idea to start with low, precisely measured doses, and have an experienced sitter present.

One of the interesting things about it is that the duration of effect is anywhere from 20 to 60 minutes.

Medical use of 5 meo DMT

the Crossroads Treatment Center in Northern Mexico, which specializes in combination ibogaine and 5-MeO-DMT therapy. It seems to work synergistically with the ibogaine, by allowing patients to integrate the ibogaine with a transcendental or mystical experience. It helps patients recontextualize their experience and ultimately can give them inspiration and motivation.

DMT also appears in many plants and animals, including the venom of a particular toad. DMT is more like a perspective shift. Some have said it’s something like a near-death experience.

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    Sania Schmitt (verified owner)

    Just like shrooms
    Shipping was faster than expected. Good product, had the same effect as shrooms for me, trip was a bit longer though. Comedown was a bit like a hangover, but maybe I just didn’t drink enough. Overall I can definitely recommend!

    April 11, 2021

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